Dopamine is an aryl hydrocarbon receptor agonist

The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor

BACKGROUND The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity and biological activity of dioxins and related chemicals. The AhR influences a variety of processes involved in cellular growth and differentiation, and recent studies have suggested that the AhR is a potential target for immune-mediated diseases. METHODOLOGY/PRINCIPAL FINDINGS...

Aryl Hydrocarbon Receptor Activation

The p53 Inhibitor Pifithrin- Is a Potent Agonist of the Aryl Hydrocarbon Receptor

The tumor suppressor protein p53 is currently a target of emerging drug therapies directed toward neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, and side effects associated with cancer treatments. Of this group of drugs, the best characterized is pifithrin, a small molecule that inhibits p53-dependent apoptosis through an undetermined mechanism. In this study, we have used a n...

ARA9 modifies agonist signaling through an increase in cytosolic aryl hydrocarbon receptor.

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the effects of agonists like 2,3, 7,8-tetrachlorodibenzo-p-dioxin. In the current model for AHR signaling, the unliganded receptor is found in the cytosol as part of a complex with a dimer of the 90-kDa heat shock protein and an immunophilin-like molecule, ARA9. In yeast, expression of ARA9 results in a...

Aryl hydrocarbon receptor is required for optimal B‐cell proliferation

The aryl hydrocarbon receptor (AhR), a transcription factor known for mediating xenobiotic toxicity, is expressed in B cells, which are known targets for environmental pollutants. However, it is unclear what the physiological functions of AhR in B cells are. We show here that expression of Ahr in B cells is up-regulated upon B-cell receptor (BCR) engagement and IL-4 treatment. Addition of a nat...